Phytother Res 25(11):16231628 Jeffery EH, Keck AS (2008) Translating knowledge generated by epidemiological and in vitro studies into dietary cancer prevention
However, the diversity of combinations and dosing regimens complicates the interpretation of results and hinders the establishment of standardized treatment protocols [51]
In human endothelial cells and animal models, empagliflozin enhances mitochondrial membrane potential, reduces mtROS production, and upregulates antioxidant enzymes (e.g., SOD2, catalase) via AMPK and Nrf2 activation
For the sample-specific models per dataset, a drug essentiality score was calculated for each drug by determining the number of samples in which the drug reduced the biomass or the ATP production below the desired threshold for cancer and healthy models, respectively
As a widespread model animal in research areas such as development, molecular genetics, toxicology and biomedicine 26,27 , zebrafish ( Danio rerio ) has been used in mechanistic studies of fish nutrition 28,29
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