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In diabetic retinopathy, a major microvascular complication affecting the retina, oxidative stress leads to damage of retinal endothelial cells

Research suggests it plays a role in several biological processes, including: Sleep/wake patterns Overall sleep quality Relaxation Alertness Cognition But this amino acid is mostly well known for its sleep benefits

10.1016/j.physbeh.2018.01.027 Physiol Behav

The Web of Science search strategy was: AB=(children OR pediatric) AND AB=(growth hormone OR growth hormone deficiency OR growth hormone treatment OR recombinant growth hormone) AND AB=(sleep quality OR sleep pattern OR sleep duration OR sleep efficiency OR sleep satisfaction OR sleep health) AND AB=(sleep study OR questionnaires OR polysomnography) NOT AB=(syndrome) NOT AB=(review OR case report)

Finally, poor oral bioavailability, incomplete toxicology, uncertain long-term effects, and the absence of controlled human trials remain major limitations

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