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This might be due to different Laser parameters used in our study, as cavities were irradiated with 2 laser cycles which might enhance the adaptation of the applied restorative material

Rx ONLY 5 PP Distributed by Hospira, Inc., Lake Forest, IL 60045 USA Hospira 12165-02 LOT:12345678 EXP:mm-yyyy PRINCIPAL DISPLAY PANEL - 50 mL Bag Pouch Label - NDC 0409-6730-50 50 mL NDC 0409-6730-50 Magnesium Sulfate in Water for Injection 4 g/50 mL (80 mg/mL) 4 g TOTAL Each 50 mL contains magnesium sulfate heptahydrate 4 g (equivalent to 32.5 mEq magnesium) in water for injection

1: CD004996

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42.4%) and achieved a skin deposition of 802.9 g/cm 2 , approximately 3.7 times greater than that of the conventional formulation

4,23,24,27,36 Recent reports suggest the skin microbiome has both intrinsic and extrinsic factors that influence skin aging (Figure 2)