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Protein S -nitrosylation, the covalent attachment of nitric oxide (NO) moiety to the reactive thiol group of a cysteine residue to form S -nitrosothiol is an important PTM for most classes of proteins ( S -nitrosylated proteins such as Bcl-2, p53, HIF-1, PTEN, and Src are involved in cell survival, angiogenesis, tumorigenesis, and response to cancer treatment (68)

Researchers study DSIP to investigate its potential roles in sleep modulation, stress response, pain control, and hormone secretion (LH, GH, ACTH)

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In some embodiments, the otic pharmaceutical formulation comprises between about 85% to about 99.99% by weight of the triglycerides