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Additionally, inadequate performance of antioxidant systems can cause OS, which is linked to damage and oxidative modification of essential molecules, including proteins and lipids, ultimately damaging RBCs themselves or other vasculature components and, thus, impairing their functions (Figure 2) [55]

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These iron ions are taken up by cells through TF and its receptors, leading to intracellular iron accumulation, which catalyzes iron-dependent Fenton reactions, producing excessive ROS that cause lipid peroxidation and membrane damage (Meng et al., 2017

Oxidative stress induced by phenylketonuria in the rat: prevention by melatonin, vitamin E, and vitamin C

Sleep Science, 12 (3), 240-241

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