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Tyrosine kinase inhibitors: multi-targeted or single-targeted

Stockwell in 2012, describes a distinctive form of cell death characterized by iron-dependent phospholipid peroxidation, underscoring the pivotal role of glutathione peroxidase 4 (GPX4) in regulating this process

Aquacult Res 9:34003410 Wang Q, He G, Wang X, Mai K, Xu W, Zhou H (2014) Dietary sulfur amino acid modulations of taurine biosynthesis in juvenile turbot ( Psetta maxima )

If a previously effective concentration suddenly yields poor results, and you can rule out other variables, peptide degradation is a likely suspect

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10.1002/hep.23797 98 KojimaH.SakuraiS.UemuraM.FukuiH.MorimotoH.TamagawaY