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Numerous other routes could allow oxidation of GSH to GSSG

Intracrine androgen synthesis may have led to restored AR signaling, leading to a rise in PSA levels and recurrent tumor growth, a relapsed state commonly referred to as castration-resistant prostatic cancer (CRPC) 8

Hydroxyl groups are attached at position 3 and 6 of morphine

PROTAC-based approaches have been developed to selectively degrade aggregation-prone proteins, including QC-01-C175 for tau in AD, XL01126 for LRRK2 in PD, and GW5074 for mutant huntingtin in HD

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However, GSH in blood is predominantly present in red blood cells (67), and erythrocyte levels could therefore be expected to be affected as well