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It regulates multiple cellular processes including proliferation, differentiation, energy metabolism, glucose homeostasis (Smith-Vikos and Slack, 2012)

Choline is taken up by cholinergic neurons from the extracellular fluid by the high-affinity choline uptake transporter (ChT) and accumulates in the synaptic terminal (where it can be combined with acetyl molecules)

In some embodiments, an otic intervention is an implantation procedure (e.g., implantation of a hearing device in the cochlea)

Fistula healing is another area with multiple positive animal studies

111 Substantial progress has been made in the development of PEG-conjugated peptides, capitalizing on the flexible and desirable characteristics of PEG (Fig