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Furthermore, oxidative stress in early development may contribute to the increased risk of neurodegeneration later in life, thus linking neurodevelopmental and neurodegenerative disorders (Litwa, 2022)

Reduced glutathione is needed to neutralize oxidative metabolites

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JCI Insight 2 , e91454 (2017)

Glutathionylated roGFP2 C151S , roGFP2 C208S , PfGrx C88S , and PfGrx C32S/C88S were produced by incubation of the reduced enzymes with 5 mM GSSG for 60 min on ice

27 Another study of 12,590 twins reveals that environment, lifestyle, and stochastic factors may also play more important roles than genetics in ACPA production while genetic factors are more responsible for the progression from ACPA-positive individuals to arthritis