Fast titration (aggressive) Week 1-2 : 2.5mg Week 3-4 : 5mg Week 5-6 : 7.5mg Week 7-8 : 10mg Week 9+ : 12.5-15mg Pros : Reach therapeutic dose faster, quicker results Cons : Higher side effect risk, lower adherence Best for : People with prior GLP-1 experience, high tolerance Slow titration (conservative) Week 1-6 : 2.5mg Week 7-12 : 5mg Week 13-18 : 7.5mg Week 19-24 : 10mg Pros : Minimal side effects, excellent tolerance Cons : Slower initial results, longer protocol Best for : Side effect-sensitive people, first-time users, health conditions Micro-dosing (very gradual) Increase by 1mg increments instead of 2.5mg jumps Example : 2.5mg 3.5mg 4.5mg 5.5mg etc
Typically, B12 injections are administered once a week
Patient provided informed consent
There was also a significant decrease in the blood levels of homocysteine, a molecule that causes damage to motor neurons and other cells in the brain and spinal cord, in treated ALS patients
doi: 10.1186/s12967-016-0771-6 93 VenterMTomasCPienaarISStrassheimVErasmusENgWFet al
Vitamin B-12 is available as an injectable vitamin with a maximum dose of 750 mcg
