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In pancreatic cancer cells, glutamine supports the production of NADPH via a noncanonical metabolic pathway 29 , and the mitochondrial glutamine transporter is strongly associated with glutaminolysis-induced NADPH generation 16

Studies across models, together with precedent from oncology, support the view that this multi-pathway engagement can be leveraged to restrain lesion growth when exposure is directed preferentially to diseased tissue

In some embodiments, the otic pharmaceutical formulation comprises between about 55% to about 95% by weight of the triglycerides

PMID 29543316

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