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In some embodiments, the otic formulation or composition comprises between about 0.001% to about 99.99% by weight of the therapeutic agent, or pharmaceutically acceptable prodrug or salt thereof

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As a result, the entire protein NMR toolbox has been developed over about 3 decades for applications on folded proteins (Bolik-Coulon et al., 2019)

Standard research protocols recommend 6090 day washouts before conception to account for tissue retention and the absence of human pregnancy-specific pharmacokinetics