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Science 335 , 14581462 (2012)

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doi:10.1021/bi002249z

Redox regulation of apoptosis: impact of thiol oxidation status on mitochondrial function

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Although oxidative stress was defined originally as a balance between oxidants and antioxidants systems, an equilibrium among antioxidant strategies is needed to avoid the generation of oxidants and ROS ( SUPEROXIDE, HYDROGEN PEROXIDE, AND PEROXYNITRITE GENERATION Despite the fact that superoxide can be generated in extramitochondrial reactions, in most cell types mitochondria appear as the main source of superoxide generation