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Mechanism of Action 5-Amino-1MQ acts as a potent and selective inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme highly expressed in adipose tissue, liver, and certain metabolically active cells

Five clinical trials in type 2-diabetic subjects (SURPASS 15) have shown that tirzepatide at 515 mg per week reduces both HbA 1c (1.24 to 2.58%) and body weight (5.411.7 kg) by amounts unprecedented for a single agent

doi: 10.1002/jcsm.12156 6 CederholmTMorleyJE

Consistent with the original report, intravenous selenium supplementation elevated serum selenium and SELENOP concentrations in the present secondary analysis

WADA was founded in 1999

In preclinical studies this reduced fat-cell size without changes to diet