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Direct pathogen contact in mouse macrophages leads to the upregulation of HIF-1 by the activation of the NF-B pathway

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There are many causes of heart failure, mainly including the excessive pressure overload during cardiac systole, the excessive volume overload during cardiac diastole, the abnormal energy metabolism of cardiomyocytes, the use of cardiotoxic drugs, and the myocardial fibrosis or ventricular remodeling (Lin et al., 2017)

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