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Annu Rev Immunol (2009) 27:66992

This three-dimensional architecture enhances persistence and functions as a local microfactory, continuously inducing mucin (e.g., MUC2) production, reinforcing tight junctions, and promoting antimicrobial peptide secretion

HUBERMAN: And injured capillaries, and then to promote the activity of a given enzyme called ENOS or endothelial nitric oxide synthase, which then causes more blood vasculature to form at the injury site and around the injury site

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Similarly, in Glioma, IDH1 mutation increases 2-hydroxyglutarate, which in turn decreases transaminase activity and leads to insufficient glutamate biosynthesis [172]

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