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In the context of LPS-activated Ms, the expression of Idh1 has been conflicting as various studies have reported its expression to be increased (53), decreased (50)

therefore, additional study is essential to identify effective therapeutic strategies targeting various pathways, including 7nAChRs

Additionally, a streptozotocin (STZ)-induced type 1 diabetes rat model, which also results in reduced insulin through cell loss, was reported to have showed decreased endothelial ZO-1 and occludin and increased MMP activity in blood (Hawkins et al., 2007), suggesting changes in vascular permeability can be a direct consequence of high blood glucose

Although not the focus of this review, it is noteworthy to mention the existence of other blood-brain/cerebrospinal fluid barriers that are essential for brain homeostasis

Drugs 24 , 107119 (2019)