For example, exogenous GSH has been recently shown to synergize with meropenem, significantly enhancing the killing of carbapenem-resistant Klebsiella pneumoniae
It degrades reduced GSH, an important antioxidant, into cysteinylglycine and 5-oxoproline, thereby decreasing the cellular antioxidant defense and increasing oxidative stress
Gupta A, Mishra R, Rai S, Bano A, Pathak N, Fujita M, et al
Bright and dark sides of nitric oxide in ischemic brain injury
Glutathione Side Effects and Safety Glutathione is generally well-tolerated in clinical settings when administered appropriately by licensed professionals
As with CYP2E1, there are substantial inter-ethnic differences in CYP2D6 across populations, ranging from complete loss of function or reduction in functional activity (2570% of the population, dependent on ethnic origin and geographical location) to extensive, ultra-rapid metabolisers (1.59.3% of the population) (see Table 3 in the supplementary data for a summary of the evidence) [17, 38]
