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Safety and efficacy of exenatide once weekly plus dapagliflozin once daily versus exenatide or dapagliflozin alone in patients with type 2 diabetes inadequately controlled with metformin monotherapy: 52-week results of the DURATION-8 randomized controlled trial

Trinity-X activates three receptors simultaneously (GLP-1, GIP, glucagon), while single-receptor peptides only target one pathway

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Fakir S, Barabutis N

Patients who received the commercial preparations twice daily for three weeks showed a significant increase in fecal levels of hBD-2 protein, while individuals treated with a placebo showed no change [118]

Thus, drastic changes in the localization of the Nt 7 constructs seem not to be followed by significant variations in their overall S-palmitoylation status