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Human clinical evidence is still limited, and further research is required to establish therapeutic applications

Why It Matters For people who follow this space, the PCAC review is the closest thing to a formal signal from the FDA on whether these compounds belong in legitimate pharmacy practice

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Investigation of MC numbers or evidence of degranulation may be missing the point, as MCs can release specific mediators via differential release mechanisms [394] such as serotonin [365,366,395] or IL-6 [365,366] or VEGF [356] without degranulation, but rather via intragranular changes [396]

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