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Individualized protocols: Cookie-cutter approaches ignore important individual variation

The only human trial ever registered (NCT02637284) was cancelled in 2016 without publishing results

A potential caveat in this study is that not all women will have poor vitamin B 12 status, and if the proportion of women with adequate status is high, this will reduce our statistical power which may result in failure to detect important differences

This hypothesis is supported by several studies that have shown supplementation with SAM improves depressive symptoms (104-107)

This product is sold strictly as a research-use reagent

However, this amount may be slightly higher for certain groups, including people who are pregnant or breastfeeding