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CHOP deficient mice were also shown to be protected against APAP-induced liver injury, though interestingly the protection was only seen in animals given APAP by gavage and not in those given APAP as an intra-peritoneal injection [87]

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Heterodimer formation by retinoid X receptor: regulation by ligands and by the receptors self-association properties

Furthermore, we also examined the level of pro-inflammatory cytokines and phosphorylation of p38 MAPK and NF-kB to further investigate whether GHK-Cu can reduce anti-inflammatory response on the peritoneal macrophages