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Nutritional intervention is expected to become the third major treatment modality alongside physical therapy and drug therapy, bringing significant benefits to patients with mild to moderate OA and effectively reducing the proportion of severe OA patients, which allow more people to avoid the adverse effects of repeated drug treatment and the potential risks of surgery and prosthesis replacement

Early Signs and Symptoms of Vitamin B12 Deficiency: Fatigue, weakness, and lack of energy: These symptoms may be brought on by inadequate vitamin B12, which lowers the synthesis of red blood cells

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NRF2 protein stability is regulated by KEAP1

Maintenance treatments are usually less frequent and less intense than the initial course of injections but can be necessary to sustain the desired effects