Sensory neurons and schwann cells respond to oxidative stress by increasing antioxidant defense mechanisms
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Its a broad and impressive preclinical dataset
Another possibility, not investigated, is that since klotho is also produced in the somatotrophs, perhaps to modulate auto/paracrine GH production, increased klotho in acromegaly could be a consequence of increased GH secretion
It supports liver detoxification, immune function, free radical control, cytokine balance, mitochondrial health, and cell repair
While systemic absorption is low, patients on oral anticoagulants or antiplatelet agents should use this product with caution, as there is a theoretical risk of increased bleeding