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accelerated FDA approval in November 2022 and full approval in March 2024 for platinum-resistant, FR-positive epithelial ovarian cancer followed evidence of high response rates and a toxicity profile dominated by reversible ocular effects rather than ovarian failure [55, 148,149,150]

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[ established significantly decreased GSH/GSSG ratio in vitro in human neutrophils upon UA treatment

its later stages demonstrate evidence of microtearing, characterized by tendon degeneration, with or without calcification, and an aborted, incomplete neurovascular response

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(2010) "Involvement of the ATI receptor subtype in the effects of angiotensin IV and LVV-haemoiphin 7 on hippocampal neurotransmitter levels and spatial working memory." J Neurochem 1 12(5): 1223-34 El-Husseini, A