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For example, it has been shown that oxidative stress is a major contributor of cardiomyocyte death in ischemia/reperfusion (I/R) injury as well as doxorubicin-induced cardiomyopathy 16,17,18,19

Its main active ingredient, total dajizin triterpenes, reduces the expression of ACSL4 in the rat model of RA, increases the expression of glutathione and GPX4, and upregulates Kelch-like ECH-associated protein 1 and HO-1 in the Nrf2/HO-1/GPX4 pathway, indicating that total dajizin triterpenes can inhibit cell aberrant ferroptosis by suppressing lipid peroxidation and thus exert therapeutic anti-RA effects [168]

Office of Dietary Supplements, National Institutes of Health Available at: Updated March 11, 2020

& Pali, D

doi:10.3390/ph17081081

Additionally, the best results are seen through consistency