Contains vitamins and selenium for antioxidant activity
An animal study in a reserpine-induced fibromyalgia rat model found that nano-pregabalin (N-PG) alleviated FM symptoms by enhancing CNS penetration, restoring neurotransmitter balance (Glut, NE, CGRP), increasing antioxidant enzyme activity (e.g., SOD), inhibiting pro-inflammatory transcription factors (e.g., NF-B), and reducing apoptosis by decreasing caspase-3 (Casp-3) activation (8, 36)
Symptoms can include chest pain, heart palpitations, and shortness of breath, while electrocardiogram (ECG) changes like tall, "peaked" T waves and a wide QRS complex may be seen
[DOI] [PMC free article] [PubMed] [Google Scholar] 183.Arrieta M.-C., Stiemsma L.T., Dimitriu P.A., Thorson L., Russell S., Yurist-Doutsch S., Kuzeljevic B., Gold M.J., Britton H.M., Lefebvre D.L., et al
doi: 10.3389/fendo.2022.1092837 37 ManggeHBeckerKFuchsDGostnerJM
Bacteria such as Lactobacillaceae and Bifidobacteriaceae species have been reported to produce riboflavin that can be used by colonic epithelial cells, but the magnitude of their in situ contribution in the gut is not yet clear 30,31
