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In Japan, ALS patients received B12 shots of 25,000-50,000mcg (each shot equal to 25-50 pernicious anemia shots all at once), at first daily and then twice a week

This is not a conservative recommendation

Abstract Pain due to spontaneous intervertebral disc (IVD) disease is common in dogs

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For instance, a growth-hormone releasing peptide may increase IGF-1 and promote follicular development, while a repair peptide decreases local inflammation and promotes tissue remodeling, synergistically enhancing the implantation milieu

Biotechniques 44 , 507511 (2008)