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42 Renal effects In people with type 2 diabetes at high risk of cardiovascular disease, liraglutide 1.8 mg daily over a median follow up of 3.8 years resulted in a 22% reduction in renal outcomes compared with placebo

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doi: 10.1161/JAHA.120.020646 153 ZhouRYangMYueCShiYTanYZhanLet al

Beneficial commensals generally promote immune tolerance and help reinforce the intestinal barrier, whereas an overgrowth of pathogenic bacteria or loss of key symbionts (dysbiosis) can provoke systemic inflammation [34]

Both pathways trigger this vesicle release, but through different intracellular signals

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