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Immunomodulation and Enhanced Immune Surveillance Aging is accompanied by a well-documented decline in immune function known as immunosenescence a state characterized by reduced T-cell proliferation, declining natural killer (NK) cell activity, and impaired antibody responses

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Sermorelin and tesamorelin both have histories as FDA-approved compounds for specific clinical contexts, while ipamorelin has only ever been studied as a research compound and is not approved for human use

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The classic Bouwstra model describes the layer as a brick-and-mortar arrangement: corneocytes (the "bricks") are tightly packed flattened cells held together by intercellular lipids (the "mortar") arranged in lamellar bilayers

In some embodiments, the suspension formulation or composition also has an immediate or rapid release component for delivery of the therapeutic agent to the desired target site