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This disrupted epidermis and the formation of an infundibular plug may also be driven by increased proliferation rates due to high circulating insulin (hyperinsulinemia) in combination with decreased IGF-1

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Liao Y, Zhao J, Bulek K, et al

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Animal procedures were conducted in accordance with the ARRIVE (Animal Research: Reporting of In Vivo Experiments) guidelines and approved by the Institutional Animal Care and Use Committee of the Affiliated Hospital of Qingdao University [AHQU-MAL20230607LH]