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In contrast to RIL-13 as an agonist, BMS-911543 (a Jak2 inhibitor) decreased IGF-1 in a dose-dependent manner in hepatocytes (Hep-Li, NCTC1469, and HepG2) of pigs, mice, and humans (Fig

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In addition to the secretion of immunosuppressive factors, MDSCs engage in direct interactions with T cells, preventing their activation and proliferation [18]