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Glutathione 250mg alone, however, was not significantly superior to placebo.52 Another recent RCT (n=46) reported decreased skin pigmentation following an 8-week regimen of 600mg of glutathione, 50mg of -lipoic acid, and 4mg of zinc.53 Even better results were observed for oral glutathione combined with topical 2% glutathione

[9] Notably, this side effect has not been noticed with NAD+ injection, in contrast to vitamin B3 (niacin) intake, which results in a flushing of the skin