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Medicinal benefits, biological, and nanoencapsulation functions of riboflavin with its toxicity profile: a narrative review

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While the immediate consequence of amplification of mitochondrial oxidant stress is loss of mitochondrial protein function due to modification of thiols [33], peroxynitrite mediated nitrotyrosine formation [48] and oxidative mitochondrial DNA damage [41], the critical event resulting in escalation of cell wide damage is induction of the mitochondrial permeability transition (MPT)

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Evellin, S