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Dihexa: Goes beyond modulation to build new synapses

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The drug likeness of new molecules is also predicted by Lipinski rule of five [25]

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doi: 10.1055/s-0035-1548790 143 JamilianMRazaviMFakhrie KashanZGhandiYBagherianTAsemiZ

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Controlling the role of BPC 157 likely involves its particular interaction with the major systems involved in wound healing, such as the NO-system (counteracted harmful events, arising from either NO-blockade or NOS-substrate application) (Sikiric et al., 2014) and the prostaglandins system (i.e., large extent of the counteracted NSAIDs toxicity (Sikiric et al., 2013) as well as counteracted developing and already formed adjuvant arthritis in rats (Sikiric et al., 1997c))

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Pretreated cells were washed with PBS, followed by incubation with 1 ml of JC-1 working solution per sample at 37 C for 20 minutes

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