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10.1007/s11418-024-01800-7 192 YiweiG.XinS.TaiqiX.NingZ

doi: 10.1073/pnas.0400282101

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Its main function is to catalyze the fourth step of the pyrimidine biosynthesis pathway, namely, the oxidation of dihydroorotate (DHO) to yield orotate (OA) and transfer electrons to ubiquinone in the inner mitochondrial membrane at the same time, so OA can be reduced to dihydroubiquinone (Fig

Glutathiones job is to act as a shield, neutralizing these molecules before they can cause cellular damage