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In contrast to histamine which is preformed in a one step reaction by decarboxylation of histidine predominantly in mast cells and basophils, cysteinyl leukotrienes (CysLTs) represent a class of immune-modulating eicosanoids which are rapidly synthesized de novo in a multi-step cascade in response to various stimuli mainly in basophils, eosinophils and mast cells and to a lower extend in macrophages and dendritic cells [14, 15]

Expert Opin Drug Deliv 20(11):15951607

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