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Artesunate induces ferroptosis by inhibiting the nuclear localization of SREBP2 in myeloma cells

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Some Fe 2+ is oxidized to Fe 3+ and stored as FT-bound inert iron, while the remaining Fe 2+ forms a LIP, inducing lipid peroxidation via the Fenton reaction, or is exported via FPN (Liu Q

The delayed cell death, mediated by cytokines, is evident at 48 h (Pang et al., 2010

Biochemical analysis of the complex revealed that GSTP1-1 interacts with TRAF2 through both G and H sites