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Concretely, GPX4 uses GSH as the substrate to reduce phospholipid hydroperoxides (PLOOHs) to hydroxyl derivatives (PLOHs), and oxidizes GSH to GSSH, therefore alleviating the damage of oxidative stress to tumor cells (Stockwell, 2022)

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5-amino-1mq, or 5-amino-1-methylquinolinium, is a synthetic small molecule compound that targets a specific enzyme involved in metabolic regulation

Journal of orthopaedic research : official publication of the Orthopaedic Research Society , 24 (5), 982-9