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Some Phase 3 trial sites are in Asia (REDEFINE 5, REDEFINE 6) but no regulatory approvals have been announced as of June 2026

SODs role in maintaining the oxidant-antioxidant balance in the body, thus protecting the body against harmful free radicals, was first determined in 1968

Blood 92(10):34953504 Pickkers P, Darmon M, Hoste E, Joannidis M, Legrand M, Ostermann M, Prowle JR, Schneider A, Schetz M (2021) Acute kidney injury in the critically ill: an updated review on pathophysiology and management

However, the synthesis of highly selective or isoform-specific inhibitors that reduce unwanted side effects still remains challenging

& Clemmensen, C