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Patients typically describe acute, severe pain in the upper-right or upper-mid region of the abdomen, often radiating to the right shoulder or between the shoulder blades

If this is the case, the toxicity caused by the expression of mutant ATXN3 fragment proteins should also be mitigated by calpain inhibition or calpastatin overexpression

The sodium-proton exchangers sNHE and NHE1 control plasma membrane hyperpolarization in mouse sperm