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Always swirl or roll the vial gently to dissolve the powder

(1) ROS directly attacks the mitochondria of chondrocytes, causing leakage of the electron transport chain (ETC) and further generating superoxide anion (O ), which forms a vicious cycle, inducing collapse of mitochondrial membrane potential and ATP synthesis disorder

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The role of the mitochondrial malic enzyme is principally to provide the cell with an alternate source of pyruvate under conditions where glycolytic flux in reduced