Firstly, it needs to be reduced to Fe 2+ by gastric acid or the action of cytochrome b heme reductase 1 (duodenal cytochrome b, DCYTB), before it can be transported into the small intestinal villus cells by divalent cation transporter 1 (DMT1)
Jaclyn AS, Richard D, Angela S, Ashley W, Andrew P, Adnan C
(PubMed) De Marco P, Calevo MG, Moroni A, et al
This allows for rapid uptake through the mucosal membranes in the mouth and the lining of the small intestine
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