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In an experimental model of male C57 black 6 (C57Bl/6) mice using a whole-body exposure system that mimics real-world exposure to air pollution for four months, exposure to concentrated ambient PM2.5 (CAP) or filtered air (FA) was found to affect sperm count, major hormones of the HPG axis, testicular histology, and mRNA expression of testosterone biosynthesis genes [216]

LPS endotoxin is a virulence factor secreted by many bacterial species, and its presence systemically is referred to as endotoxemia

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