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SLC1A5 might not be an appropriate target for suppressing glutamine uptake by cancer cells because it is not the only plasma membrane glutamine transporter, and its function would therefore be compensated by other redundant glutamine transporters such as SLC38A1 and SLC38A2

The RAM consists of two distinct components: the extracellular matrix and stromal cells, which exhibit marked differences from those found in healthy tissues [7, 10]

Thyroid (2002) 12(10):86778

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Their synergistic mechanisms amplify individual benefits, making combination therapy more effective than either molecule alone