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In addition, the increased MDA values counteraction occurred in all organs simultaneously, as specifically shown in the therapeutic effect investigated in rats that had intra-abdominal hypertension (grade III and grade IV), decompression, and reperfusion [133,134]

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We have recently shown that the collateral sensitivity of resistant cells to these drugs is dependent on P-gp expression and activity, whereby stimulation of its ATPase activity triggers a rise in reactive oxygen species (ROS) leading to heightened oxidative cell death of resistance cells [14,15,16,17]