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13) Addictions Various drugs of abuse (such as cocaine and methamphetamines), as well as alcohol, increase the production of reactive oxygen species

Kaufman, J.-M., Lapauw, B., Mahmoud, A., TSjoen, G

Chest 114, 16681675

In the patients that have been clearly diagnosed with D2L2AD the consistent clinical manifestations include severe neonatal epileptic encephalopathy, often accompanied by respiratory insufficiency requiring artificial ventilation