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Dosing considerations differ, and women on estrogen-containing therapies may respond differently due to estrogens effect on GH sensitivity

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Researchers have proposed several mechanisms, including direct effects on gene transcription factors and indirect influences through cellular signaling cascades that regulate telomerase activity

Sikiric, P., Seiwerth, S., Ruman, R., Turkovi, B., Rokotov, D., Bri, L., Sever, M., Klicek, R., Radi, B., Drmic, D., Ili, S., Kolenc, D., Stambolija, V., Zorii, Z., Vri, H., & ebei, B