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On the other hand, a restriction in lactose intake is suggested in hypothyroid patients in need for levothyroxine treatment affected by lactose malabsorption, a condition with a global prevalence of 68%, due to the non-persistence of the expression of lactase gene [154]

doi: 10.1016/j.biopha.2018.06.057, 13

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The CG methylation is thought to alter chromatin density and DNA accessibility by blocking the binding of TFs to their cognate DNA sequences and/or increasing the recruitment of the methyl-binding proteins and histone deacetylases (Bird, 2002)

Clinical data also showed no significant abuse or dependence potential

Lycopene and beta-carotene induce cell-cycle arrest and apoptosis in human breast cancer cell lines