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It also protects the cardiac microvascular system from reperfusion injury through VDAC1-HK2-mPTP-induced mitophagy [122]

In contrast, these outcomes were reversed by the FXR agonist GW4064

The Zr released from Mn-MOF downregulated GSH efficiently (Figure 5G), thus elevating Mn-MOF-induced ROS concentration, leading to the deactivation of GPX4 and ROS-enhanced ferroptosis

These proteins, called selenoproteins, are the foundations of many biological processes that help maintain cellular redox balance [1]

The primer sequences used are provided below: Human HKDC1 promoter, 5-ATTACAGGCGTGAGCCACTG-3 (S3, forward) 5-AGCAGCCCGTTTCACTTAGA-3 (S3, reverse)